某种肠道细菌
粘蛋白
寄主(生物学)
生物
疣状疣
免疫系统
细菌
微生物学
生态学
免疫学
肠道菌群
生物化学
遗传学
16S核糖体RNA
放线菌门
作者
Qixiang Zhao,Jiadong Yu,Yan Hao,Hong Zhou,Yawen Hu,Chen Zhang,Huaping Zheng,Xiaoyan Wang,Fanlian Zeng,Jing Hu,Linna Gu,Zhen Wang,Fulei Zhao,Chengcheng Yue,Pei Zhou,Haozhou Zhang,Nongyu Huang,Wenling Wu,Yifan Zhou,Jiong Li
标识
DOI:10.1080/1040841x.2022.2037506
摘要
Akkermansia muciniphila, an intestinal microorganism, belongs to Verrucomicrobia, one of the most abundant microorganisms in the mammalian gut. It is a mucin-degrading bacterium that can colonise intestines of mammals such as humans and mice by utilising mucin as the only nitrogen and carbon source. When A. muciniphila colonises the intestine, its metabolites interact with the intestinal barrier, affecting host health by consolidating the intestinal barrier, regulating metabolic functions of the intestinal and circulatory systems, and regulating immune functions. This review summarised the mechanisms of A. muciniphila-host interactions that are relevant to host health. We focussed on characteristics of A. muciniphila in relation to its metabolites to provide a comprehensive understanding of A. muciniphila and its effects on host health and disease processes.
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