光动力疗法
氧化还原
化学
活性氧
平衡
谷胱甘肽
生物物理学
纳米医学
癌症研究
癌症治疗
肿瘤微环境
癌症
细胞生物学
肿瘤细胞
生物化学
纳米技术
生物
医学
材料科学
内科学
纳米颗粒
酶
有机化学
作者
Yang Ni,Rongrong Zheng,Ziying Chen,Rui‐Xin Wang,Lin‐Ping Zhao,Xia-Yun Chen,Lei Chen,Lin Xu,Shiying Li,A‐Li Chen
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:10 (6): 1575-1581
被引量:8
摘要
Abnormal tumor microenvironments play important roles in cancer progression. In general, tumor cells are capable of upregulating glutathione (GSH) levels to maintain aberrant redox homeostasis and cause resistance to oxidative damage. Herein, we develop a photodynamic oxidizer to disrupt the redox homeostasis of tumor cells for enhanced photodynamic tumor therapy. Based on pyropheophorbide-a (Pyro) and naphthazarin (Nap), a carrier free photodynamic oxidizer (named PyroNap) is prepared by the self-assembly technique through hydrophobic interactions. It is confirmed that nanosized PyroNap has high drug contents as well as favorable dispersity and stability. Besides, the photodynamic property of Pyro has obviously improved after self-assembly into the nanomedicine of PyroNap, which facilitates the production of reactive oxygen species (ROS) for robust photodynamic therapy (PDT). More importantly, the Nap induced GSH decrease could disrupt the redox homeostasis of tumor cells to further improve the PDT efficacy on tumor suppression. Consequently, after intravenous administration, PyroNap was able to significantly inhibit tumor growth and cause minimal side effects. This study might shed light on developing translational nanomedicine for tumor precision therapy.
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