Mesoporous yolk–shell structured nanoreactors with metal nanoparticle cores and inorganic-organic hybrid shells are successfully synthesized using a simple soft templating method, as reported on page 591 by Gao Qing (Max) Lu, Shi Zhang Qiao, and co-workers. Taking advantage of the unique structures, the obtained nanoreactors with Au, Pt, and Pd nanoparticle catalysts achieve high conversion and selectivity for selective alcohol oxidation reactions.