Aluminium(III) Chloride‐Catalyzed Three‐Component Condensation of Aromatic Aldehydes, Nitroalkanes and Sodium Azide for the Synthesis of 4‐Aryl‐NH‐1,2,3‐triazoles

Abstract An aluminium(III) chloride‐catalyzed three‐component reaction of aromatic aldehydes, nitroalkanes, and sodium azide has been developed; this reaction sequence can be applied to a broad substrate scope and affords the corresponding 4‐aryl‐ NH ‐1,2,3‐triazoles in good to excellent yields. The milder reaction conditions and easier operation make this AlCl 3 ‐catalyzed protocol more advantageous for the synthesis of 4‐aryl‐ NH ‐1,2,3‐triazoles. magnified image