Research Progress on Sorafenib Combined with Intervention in the Treatment for Advanced Hepatocellular Carcinoma

Sorafenib is a multi-targeted small molecule kinase inhibitors for advanced liver cancer. Clinical trails of sorafenib treatment for phase Ⅲ primary liver cancer showed that it can improve the survival rate of the patients significantly. Interventional treatment,such as radiofrequency ablation and transarterial chemoembolization,has achieved satisfactory clinical results as an important means to treat unresectable advanced hepatocellular carcinoma,which has achieved,which has provided more options for non-operative treatment for advanced liver cancer. The positive effect of sorafenib combined with interventional therapy on advanced liver cancer has been reported in the literatures. Here is to make a review of the biological therapy,interventional therapy for advanced liver cancer,in order to help for clinicians in selecting proper treatment for advanced liver cancer.