Efficacy of Tripterygium Wilfordii in Treating Psoriasis Vulgaris: A Systematic Review on Randomized Controlled Trials

Objective To evaluate the therapeutic effect of Tripterygium Wilfordii on psoriasis vulgaris by systematic review of the randomized controlled trials(RCTs) in treating psoriasis vulgaris.Methods The RCTs of Tripterygium Wilfordii in treating psoriasis vulgaris were retrieved from Cochrane Library(Issue 3,2012),PubMed(1966-2012),EMbase(1974-2012),Wan Fang Data(1990-2012),VIP(1989-2012),CNKI(1980-2012),Wan Fang Dissertation Data(1990-2012) and Wan Fang Conference Data(19902012).Methodological quality assessment and data extraction assessment for methodological quality was using a modification of criterriagive in Cochrane Reviewers’ Handbook.RevMan 4.2 was used for Meta-analysis.Odds ratio(OR) and 95% confidence intervals(95%CI) were used to analyze the efficacy.Results Fourteen papers of RCTs were included.Two papers of Tripterygium Wilfordii plus Retinoids and 3 papers of Tripterygium Wilfordii plus Diyin Tablet were analyzed by fixed effect model,others were descriptively analyzed.The results showed that Tripterygium Wilfordii was effective on psoriasis vulgaris.Conclusion The therapeutic effect of Tripterygium Wilfordii in treating psoriasis vulgaris is assured,but the evidence of large,multicenter RCTs are urgently needed,so as to provide more convincible evidence.