Research Progress on Bacterial Quorum Sensing Inhibitors

Bacteria can produce chemical signal molecules and secret them into the surrounding environment during their growth processes.When the number of signal molecules reaches to a certain threshold,the related genes expression,such as biofilm formation or bioluminescent,will be regulated,in order to adapt to such environmental changes.This phenomenon is called bacterial quorum sensing(QS).Using bacterial quorum sensing as a target,bacterial quorum sensing inhibitors(QSI)make pathogens lose pathogenicity by blocking the expression of harmful genes,whilst do not kill the normal bacteria or interfere with the normal physiological activity of bacteria,which providing a new antibacterial way for mankind.Research progress on signal molecules regulation system of bacterial quorum sensing system and bacterial quorum sensing inhibitors are reviewed in this paper.