Induced Proximity Beyond PROTACs: Computational Discovery of Molecular Glues, Degrader Mechanisms, Ternary Complexes, and Emerging Therapeutic Modalities

Induced proximity has emerged as a transformative strategy in drug discovery, extending far beyond the classical PROTAC paradigm. This review explores computational approaches for the discovery of molecular glues, elucidation of degrader mechanisms, prediction and modeling of ternary complexes, and the development of emerging therapeutic modalities. Molecular glues stabilize protein–protein interactions without the need for a linker, offering new opportunities to degrade previously undruggable t