Cobalt‐Catalyzed Reductive Alkylation of Amines with Carboxylic Acids

Abstract Direct reductive alkylation of amines with carboxylic acid is carried out by using an inexpensive, air‐stable cobalt/triphos catalytic system with molecular hydrogen as the reductant. This efficient synthetic method proceeds through reduction and condensation, followed by reduction of the in situ‐generated imine into the amine in a green catalytic process.