鞘脂
急性肾损伤
发病机制
肾
肾功能
炎症
医学
活性氧
生物
病理
免疫学
内科学
细胞生物学
作者
Tess V. Dupre,Leah J. Siskind
出处
期刊:Advances in biological regulation
日期:2018-12-01
卷期号:70: 31-39
被引量:12
标识
DOI:10.1016/j.jbior.2018.11.003
摘要
Acute kidney injury (AKI) is most simply defined as the rapid loss of kidney function in a matter of hours to days. AKI can manifest in a number of ways including pre-renal, post-renal, or intrinsic AKI. During acute kidney injury, multiple pathogenic processes are activated including inflammation, cell death, and the generation of reactive oxygen species, just to name a few. Sphingolipids are known to play a role in a number of the pathogenic pathways involved in the pathogenesis of many types of AKI, which suggests a role for sphingolipids in AKI. This short review will discuss the evidence for a role for sphingolipids in AKI.
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