Voxel‐based quantitative susceptibility mapping in Parkinson's disease with mild cognitive impairment

库尼乌斯 定量磁化率图 楔前 舌回 蒙特利尔认知评估 认知 帕金森病 心理学 医学 基于体素的形态计量学 神经科学 内科学 听力学 体素 疾病 认知障碍 磁共振成像 放射科 白质
作者
Yuto Uchida,Hirohito Kan,Keita Sakurai,Nobuyuki Arai,Daisuke Kato,Shoji Kawashima,Yoshino Ueki,Noriyuki Matsukawa
出处
期刊:Movement Disorders [Wiley]
卷期号:34 (8): 1164-1173 被引量:83
标识
DOI:10.1002/mds.27717
摘要

Abstract Objective Brain iron accumulation has been proposed as one of the pathomechanisms in Parkinson's disease (PD). This study aimed to examine the whole‐brain pattern of iron accumulation associated with cognitive impairment in patients with PD using voxel‐based quantitative susceptibility mapping analysis. Methods We enrolled 24 patients with PD and mild cognitive impairment, 22 patients with PD and normal cognition, and 20 age‐matched healthy controls in this cross‐sectional study. All participants underwent global cognitive and physical assessments and brain MRI. Using a combined method of voxel‐based morphometry and quantitative susceptibility mapping, we compared the voxel‐wise magnetic susceptibility of the whole brain between the groups and analyzed its correlation with the cognitive and behavioral data. Results The PD and mild cognitive impairment group had lower Montreal Cognitive Assessment (MoCA) score than the PD and normal cognition and healthy control groups. There were no gray matter volumetric differences between the groups. In contrast, the voxel‐based quantitative susceptibility mapping analysis showed that the PD and mild cognitive impairment group had significantly higher quantitative susceptibility mapping values in the cuneus, precuneus, caudate head, fusiform gyrus, and orbitofrontal cortex than did the PD and normal cognition group. These quantitative susceptibility mapping values were negatively correlated with the MoCA scores in the PD patients (cuneus: r = −0.510, P < .001; caudate head: r = −0.458, P = 0.002). Conclusions This study suggests that cognitive impairment in PD is associated with cerebral iron burden and highlights the potential of quantitative susceptibility mapping as an auxiliary biomarker for early evaluation of cognitive decline in patients with PD. © 2019 International Parkinson and Movement Disorder Society
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