Synthesis of Hollow Nanospherical Cuprous Oxide Supported by Nitrogen‐Doped Reduced Graphene Oxide and Its Application to Enzyme‐Free Glucose Sensing

Abstract Nitrogen‐doped reduced graphene oxide (N‐rGO) was obtained via high temperature heat treatment using ammonia as a nitrogen source. EDS and XPS tests revealed that the nitrogen atoms have been doped into the skeleton of graphene successfully. On this basis, hollow nanospherical cuprous oxide supported by N‐rGO (HNS‐Cu 2 O/N‐rGO) was synthesized by chemical precipitation as electrode materials for detection of glucose. TEM test showed that the hollow spherical cuprous oxide has been successfully supported on the surface of N‐rGO. In the case of electrochemical studies, the HNS‐Cu 2 O/N‐rGO modified glass carbon electrode presented a linear range from 4 μM to 2.37 mM for glucose detection with a sensitivity of 2488.8 μA⋅mM −1 ⋅cm −2 , a detection limit of 2.28 μM (S/N=3) and fast amperometric response. Furthermore, the nanocomposite displayed good selectivity for glucose detection in the presence of interferences. The entire analysis demonstrates the applicability of HNS‐Cu 2 O/N‐rGO nanocomposite as one of the futuristic sensing material for glucose detection.