单线态氧
材料科学
光敏剂
光动力疗法
生物物理学
内化
体内
细胞内
氧气
纳米技术
化学
光化学
细胞
有机化学
生物
生物化学
生物技术
作者
Lihuang Wu,Xiaojun Cai,Haofang Zhu,Junhua Li,Dongxu Shi,Dunfan Su,Yue Dong,Zhongwei Gu
标识
DOI:10.1002/adfm.201804324
摘要
Abstract The precise delivery and controllable release of carbon monoxide (CO) to tumor tissues is an emerging anticancer therapy because CO in a high dose can be detrimental to cell survival and tumor growth. However, CO gas therapy is limited by the gaseous nature of CO that hinders its enrichment and controllable release to tumor tissues. Here, a novel photodynamic therapy (PDT)‐driven CO controllable release system (CORM@G3DSP‐Ce6) that integrates the photosensitizer chlorin e6 (Ce6) and H 2 O 2 ‐sensitive CO releasing molecule CORM‐401 into peptide dendrimer‐based nanogels (G3DSP) is described. Upon excitation with near‐infrared light, Ce6‐mediated photochemical effect not only promotes the efficient cellular internalization of CORM@G3DSP‐Ce6, but also triggers the rapid intracellular CO release from CORM‐401 by depleting the H 2 O 2 produced during PDT. Importantly, the PDT‐driven CO release does not impair the generation capability of singlet oxygen ( 1 O 2 ). As a result, accompanied with the simultaneous generation of large amounts of 1 O 2 and CO in cells, the combination of PDT and CO gas therapy offers significant synergistic anticancer effects and superior therapeutic safety both in vitro and in vivo.
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