An exopolysaccharide (EPS) from a Lactobacillus plantarum BR2 with potential benefits for making functional foods

A high molecular weight EPS of glucomannan nature was recovered and purified to get an yield of 2.8 ± 0.5 g/L from Lb. plantarum BR2 and it displayed potent antioxidant activity with 29.8% radical scavenging activity and 19% total antioxidant capacity. At 100 µg/ml concentration, it is capable of inhibiting the alpha amylase activity by 10% and at 300 µg/ml, it drastically inhibited the alpha-glucosidase activity by 67% which indicates its antidiabetic potential. More interestingly, at a concentration level of 0.1%, it reduced the cholesterol level by a margin of 45% in an in vitro assay. The sample didn’t reveal any cytotoxicity against H9C2 normal cells indicating its potential for safe use as a food additive.