胺化
铑
化学
配体(生物化学)
催化作用
键裂
钯
组合化学
药物化学
环戊二烯基络合物
立体化学
有机化学
受体
生物化学
作者
Huaiwei Wang,Yi Lu,Bing Zhang,Jian He,Huajin Xu,Yan‐Shang Kang,Wei‐Yin Sun,Jin‐Quan Yu
标识
DOI:10.1002/anie.201703300
摘要
Ligand development for rhodium(III)-catalyzed C-H activation reactions has largely been limited to cyclopentadienyl (Cp) based scaffolds. 2-Methylquinoline has now been identified as a feasible ligand that can coordinate to the metal center of Cp*RhCl to accelerate the cleavage of the C-H bond of N-pentafluorophenylbenzamides, providing a new structural lead for ligand design. The compatibility of this reaction with secondary free amines and anilines also overcomes the limitations of palladium(II)-catalyzed C-H amination reactions.
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