2-Azetidinones in One-Pot from Imines and Carboxylic Acids via 1,4-Dichlorophthalazine

Background: β-Lactam antibiotics are plenty applied for the treatment of bacterial infections.Other biological activities and utilizing as a building block of 2-azetidinones is also well reported. The most useful method for the synthesis of 2-azetidinones is the Staudinger reaction. Generally ketenes were prepared from acyl halides which acyl halides shows unfavorable results such as low stability, low yield of products, and difficulties in handling and preparation. Keywords: β-Lactam, 2-azetidinone, Staudinger reaction, 1, 4-dichlorophthalazine, ketene, imine.