生物正交化学
光动力疗法
点击化学
单线态氧
癌症治疗
乙二醇
纳米颗粒
材料科学
纳米技术
PEG比率
光敏剂
荧光
辐照
生物物理学
聚集诱导发射
组合化学
光化学
化学
癌症
有机化学
氧气
医学
内科学
核物理学
经济
物理
生物
量子力学
财务
作者
Jingjing Liu,Fang Hu,Min Wu,Longlong Tian,Fei Gong,Xiaoyan Zhong,Muchao Chen,Zhuang Liu,Bin Liu
标识
DOI:10.1002/adma.202007888
摘要
Radiodynamic therapy (RDT), an emerging therapeutic approach for cancer treatment by employing ionizing irradiation to induce localized photodynamic therapy (PDT) can overcome the drawbacks of the limited penetration depth for traditional PDT and the unconcentrated energy in the tumor for traditional radiotherapy (RT). Taking advantage of aggregation-induced emission (AIE) photosensitizers with bright fluorescence and efficient singlet oxygen production in the aggregate state, Hf-AIE coordination polymer nanoparticles (CPNs), which show both strong RT and RDT effect under X-ray irradiation, are developed. Furthermore, to enhance the tumor accumulation and prolong the tumor retention of the CPNs, bioorthogonal click chemistry is applied in the system through coupling between dibenzocyclooctyne (DBCO)-modified CPNs (Hf-AIE-PEG-DBCO) (PEG: poly(ethylene glycol)) and azide groups on the cell membrane formed by metabolic glycoengineering. Thanks to the high penetration of X-ray irradiation, the bioorthogonal-assisted RT and RDT combination therapy realizes significant killing of cancer cells without showing noticeable biotoxicity after intravenous administration of CPNs.
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