The Role of Nucleophosmin in Cell Functioning and Tumor Progression

Abstract Nucleophosmin/B23/NPM is a multifunctional protein that regulates the most important processes of cell viability and apoptosis. Disturbances in the NPM gene structure and expression of the B23 protein encoded by this gene play an important role in the development and progression of oncological, neurological, and other diseases. The review considers the structure of the NPM gene and the B23 protein, the functions of nucleophosmin, and its role in carcinogenesis from the standpoint of applied and fundamental molecular biological aspects of modern oncology.