‘In Silico’ Simulation of Biological Processes

Chair's Introduction (D. Noble). Integrative biological modelling in silico (A. McCulloch and G. Huber). Advances in computing, and their impact on scientific computing (M. Giles). From physics to phenomenology: Levels of description and levels of selection (D. Krakauer). Making sense of complex phenomena in biology (P. Maini). On ontologies for biologists: the Gene Ontology-untangling the web (M. Ashburner and S. Lewis). General discussion I: Model validation. The KEGG database (M. Kanehisa). Shanka Subramaniam and the Bioinformatics Core Laboratory Bioinformatics of cellular signalling. General discussion II: Standards of communication. Semantics and intercommunicability. Imaging-based integrative models of the heart: closing the loop between experiment and simulation (R. Winslow, et al.). General discussion III: Modelling Ca2+ signalling. The Virtual Cell project (L. Loew). Modelling the bacterial chemotaxis receptor complex (T. Shimizu and D. Bray). The heart cell in silico: successes, failures and prospects (D. Noble). General discussion IV. The IUPS Physiome Project (P. Hunter, et al.). Using in silico biology to facilitate drug development (J. Levin, et al). Final discussion: Is there a theoretical biology? Index of contributors. Subject index.