医学
扬抑
狭窄
冠状动脉疾病
心脏病学
内科学
碲锌镉
核医学
放射科
右冠状动脉
动脉
铊
冠状动脉造影
心肌梗塞
化学
无机化学
工程类
电气工程
探测器
作者
Taishiro Chikamori,Kenji Goto,Satoshi Hida,Masao Miyagawa,Hayato Ishimura,Kenji Uchida,Takeshi Fukuyama,Takashi Mochizuki,Akira Yamashina
标识
DOI:10.1016/j.jjcc.2016.02.020
摘要
Despite the introduction of the novel cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) in Japan; its diagnostic value in clinical practice remains largely unknown.The Semiconductor SPECT Study group is a multicenter Japanese registry which registered 1000 patients to evaluate the diagnostic utility of the CZT camera system (Discovery NM530c; GE Healthcare, Haifa, Israel). The patients underwent stress myocardial SPECT and coronary angiography within a 3-month interval. A significant stenosis was defined as ≥75% diameter narrowing based on the American Heart Association classification.Technetium (99mTc) radiotracer (555-1110MBq) was used in 71% and thallium-201 (201Tl) (74-148MBq) in 29%. The scan times with 99mTc-radiotracer were 5-10min for stress and 3-10min for rest, whereas those with 201Tl were 5-9min for stress and 8-10min for rest. To detect individual coronary stenosis, the respective sensitivities, specificities, and accuracies were 74%, 85%, and 81% for left anterior descending coronary artery (LAD) stenosis, 76%, 89%, and 85% for left circumflex stenosis, and 72%, 86%, and 82% for right coronary artery stenosis. However, 66% sensitivity and 91% specificity for LAD stenosis were observed with 99mTc-radiotracer, whereas 88% sensitivity and 63% specificity were found with 201Tl.The novel CZT SPECT system facilitated a short scan time with reduced radiotracer dose, yielding an acceptable diagnostic performance for angiographical coronary artery disease, although the low sensitivity for LAD detection with 99mTc-radiotracer needs to be refined.
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