区域选择性
化学
糖基转移酶
立体化学
酶
芒果
葡萄糖苷
生物合成
尿苷二磷酸
催化作用
生物化学
生物
植物
医学
病理
替代医学
作者
Fan Chen,Lili Sun,Ridao Chen,Kebo Xie,Lin Yang,Jungui Dai
标识
DOI:10.1002/chem.201600411
摘要
A green and cost-effective process for the convenient synthesis of acylphloroglucinol 3-C-glucosides from 2-O-glucosides was exploited using a novel C-glycosyltransferase (MiCGTb) from Mangifera indica. Compared with previously characterized CGTs, MiCGTb exhibited unique de-O-glucosylation promiscuity and high regioselectivity toward structurally diverse 2-O-glucosides of acylphloroglucinol and achieved high yields of C-glucosides even with a catalytic amount of uridine 5′-diphosphate (UDP). These findings demonstrate for the first time the significant potential of a single-enzyme approach to the synthesis of bioactive C-glucosides from both natural and unnatural acylphloroglucinol 2-O-glucosides.
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