佐剂
Zeta电位
免疫系统
纳米颗粒
锌
免疫增强剂
细胞因子
分泌物
免疫佐剂
镁
材料科学
体外
核化学
化学
纳米技术
生物
生物化学
免疫学
冶金
作者
Xiupeng Wang,Xia Li,Atsuo Ito,Yohei Watanabe,Yu Sogo,Motohiro Hirose,Tadao Ohno,Noriko M. Tsuji
标识
DOI:10.1016/j.colsurfb.2015.12.004
摘要
A Th1 immune response is required for modern vaccines as the most commonly used alum adjuvant has weak capacity for inducing Th1 immune response. Herein, rod-shaped hydroxyapatite (HA), magnesium-substituted HA (MgHA) and zinc-substituted HA (ZnHA) nanoparticles with irregular nanopores were synthesized and used as immunoadjuvants. Magnesium and zinc substitution in HA showed no influence on morphology, particle size, zeta potential and surface area of the nanoparticles. The rod-shaped MgHA and ZnHA nanoparticles promoted the cellular uptake of a molecular immunopotentiator, stimulated both type 1 and 2 cytokine secretion in vitro that relate to Th1 and Th2 immunity of bone marrow dentritic cells, respectively. The MgHA and ZnHA nanoparticles may be useful as immunoadjuvants for human.
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