MINOCYCLINE IMPROVES MEMORY IN MORRIS WATER MAZE TASK IN INTRACEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS Research Article

In the present study, the effect of minocycline was studied against intracerebroventricular streptozotocin induced spatial memory deficit. Male wistar rats were injected with intracerebroventricular streptozotocin bilaterally. The rats were treated chronically with Minocycline (10, 20 and 40 mg/kg, ip) for 17 days starting from day 1 of streptozotocin injection in separate groups. The spatial memory was evaluated using the Morris water maze task. The intracerebroventricular streptozotocin infused rats showed significant memory deficits and minocycline showed significant dose dependent improvement in the task. The study demonstrated the effectiveness of minocycline in preventing spatial memory deficit induced by streptozotocin and its potential in age related neurodegenerative disorders where memory impairment is involved such as Alzheimer's disease.