Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

肿瘤微环境 化学 癌症治疗 癌症 纳米颗粒 纳米技术 医学 内科学 材料科学
作者
Simon N. Mbugua
出处
期刊:Bioinorganic Chemistry and Applications [Hindawi Publishing Corporation]
卷期号:2022 (1) 被引量:25
标识
DOI:10.1155/2022/5041399
摘要

Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen‐dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
研友_VZG7GZ应助麦兜兜采纳,获得10
1秒前
3秒前
熊小熊XIONG完成签到,获得积分10
3秒前
4秒前
4秒前
浮游应助Vegccc采纳,获得10
7秒前
量子星尘发布了新的文献求助10
9秒前
xuan发布了新的文献求助10
9秒前
刘国利发布了新的文献求助30
9秒前
慕青应助东北师范大学采纳,获得10
11秒前
fxf完成签到,获得积分10
12秒前
12秒前
13秒前
ding完成签到,获得积分10
15秒前
15秒前
15秒前
15秒前
16秒前
海绵宝宝完成签到,获得积分10
17秒前
yjx完成签到,获得积分20
17秒前
Dean应助Lio采纳,获得80
17秒前
18秒前
18秒前
18秒前
18秒前
tan126391完成签到,获得积分10
19秒前
理工发布了新的文献求助10
19秒前
田江立发布了新的文献求助10
20秒前
passerby发布了新的文献求助10
20秒前
VTMS完成签到,获得积分10
20秒前
22发布了新的文献求助10
21秒前
852应助怕孤单的血茗采纳,获得10
21秒前
糊涂涂发布了新的文献求助10
22秒前
ding应助调皮的醉山采纳,获得10
22秒前
ya发布了新的文献求助10
23秒前
24秒前
烟花应助理工采纳,获得10
25秒前
量子星尘发布了新的文献求助10
25秒前
生动的若之完成签到 ,获得积分10
25秒前
ding发布了新的文献求助30
25秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Разработка технологических основ обеспечения качества сборки высокоточных узлов газотурбинных двигателей,2000 1000
Vertebrate Palaeontology, 5th Edition 510
ISO/IEC 24760-1:2025 Information security, cybersecurity and privacy protection — A framework for identity management 500
碳捕捉技术能效评价方法 500
Optimization and Learning via Stochastic Gradient Search 500
Nuclear Fuel Behaviour under RIA Conditions 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 物理化学 基因 催化作用 遗传学 冶金 电极 光电子学
热门帖子
关注 科研通微信公众号,转发送积分 4691578
求助须知:如何正确求助?哪些是违规求助? 4063135
关于积分的说明 12563083
捐赠科研通 3761107
什么是DOI,文献DOI怎么找? 2077260
邀请新用户注册赠送积分活动 1105809
科研通“疑难数据库(出版商)”最低求助积分说明 984412