化学
全合成
杂蒽
试剂
立体化学
衍生工具(金融)
格氏试剂
序列(生物学)
代谢物
组合化学
有机化学
生物化学
金融经济学
经济
作者
Takashi Matsumoto,Ryouma Kobayashi,Yu Watabe,Yuuki Fujimoto,Hikaru Yanai
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2022-12-19
卷期号:34 (08): 953-957
被引量:1
标识
DOI:10.1055/s-0042-1751395
摘要
Abstract The first total synthesis of patulone, a plant metabolite possessing a unique 1,1-diisoprenyl-1H-xanthene-2,9-dione structure, is described. Starting from a 1-fluroxanthone derivative with suitable substitution pattern, the pivotal gem-diisoprenylation was efficiently accomplished by implementing twice the sequence of addition of isoprenyl Grignard reagent to the carbonyl at C9 and anion-accelerated oxy-Cope rearrangement.
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