禁欲
上瘾
心理学
海洛因
渴求
医学
纵向研究
精神科
神经科学
药品
病理
作者
Shan Zhang,Wenhan Yang,Minpeng Li,Xinwen Wen,Ziqiang Shao,Jun Li,Jixin Liu,Jun Zhang,Dahua Yu,Jun Li,Kai Yuan
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2024-06-01
卷期号:22 (6): 1144-1153
标识
DOI:10.2174/1570159x21666221129105408
摘要
Background: Brain recovery phenomenon after long-term abstinence had been reported in substance use disorders. Yet, few longitudinal studies have been conducted to observe the abnormal dynamic functional connectivity (dFNC) of large-scale brain networks and recovery after prolonged abstinence in heroin users. Objective: The current study will explore the brain network dynamic connection reconfigurations after prolonged abstinence in heroin users (HUs). Methods: The 10-month longitudinal design was carried out for 40 HUs. The 40 healthy controls (HCs) were also enrolled. Group independent component analysis (GICA) and dFNC analysis were employed to detect the different dFNC patterns of addiction-related ICNs between HUs and HCs. The temporal properties and the graph-theoretical properties were calculated. Whether the abnormalities would be reconfigured in HUs after prolonged abstinence was then investigated. Results: Based on eight functional networks extracted from GICA, four states were identified by the dFNC analysis. Lower mean dwell time and fraction rate in state4 were found for HUs, which were increased toward HCs after prolonged abstinence. In this state, HUs at baseline showed higher dFNC of RECN-aSN, aSN- aSN and dDMN-pSN, which decreased after protracted abstinence. A similar recovery phenomenon was found for the global efficiency and path length in abstinence HUs. Mean while, the abnormal dFNC strength was correlated with craving both at baseline and after abstinence. Conclusion: Our longitudinal study observed the large-scale brain network reconfiguration from the dynamic perspective in HUs after prolonged abstinence and improved the understanding of the neurobiology of prolonged abstinence in HUs.
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