Cardio-systemic Stress and Trained Innate Immune Memory in Heart Failure

1Center for Advanced Heart Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Received 28 July 2024. Revision received 1 October 2024. Accepted 6 October 2024. M.R.M. reported receiving consulting fees paid to Brigham and Women's Hospital from Abbott during the conduct of the study and personal fees from Moderna, Natera, Transmedics, Cadrenal, Second Heart Assist, Paragonix, NupulseCV, FineHeart, FIRE1, and Leviticus outside the submitted work. The other author declares no conflicts of interest. A.I. and M.R.M. contributed equally to this article and developed the concept, draft, rewriting, and final review. M.R.M. provided supervision for this article. Correspondence: Mandeep R. Mehra, MD, Brigham and Women's Hospital, 15 Francis St, AB 326, Boston MA 02115. ([email protected]).