Effect of intradialytic weight resistance training exercise in sarcopenic hemodialysis patients: A randomized controlled trial

Abstract Background Sarcopenia has a high prevalence in end‐stage kidney disease (ESKD). However, there is limited evidence of resistance exercise in these patients. Objective The study investigated the effects of resistance exercise on muscle mass, strength, and physical functioning. Method Fifty‐three patients were randomly assigned to resistance training exercise ( n = 26) and standard exercise ( n = 27) groups. All of the patients were diagnosed with sarcopenia by the Asian Working Group for Sarcopenia 2019 criteria. Results After 12 weeks, an improvement in leg muscle strength was significantly greater in the resistant exercise group compared with standard exercise (12.19 vs. 2.83 kg, p < 0.001). Appendicular skeletal muscle mass had a mean difference (1.01 vs. 1.02 kg/m 2 , p = 0.96). Physical performance status had a mean difference (−2.3 vs. −18 s, p = 0.42). There were no serious adverse events. Conclusion Over a 12‐week follow‐up, resistance exercise improved muscle strength in sarcopenic ESKD patients. Muscle mass and physical performance showed no significant change, but there is still a trend demonstrating to improve.