光遗传学
消光(光学矿物学)
神经科学
恐惧条件反射
扁桃形结构
边缘下皮质
大脑中的恐惧处理
转录组
心理学
生物
前额叶皮质
认知
基因
基因表达
遗传学
古生物学
作者
Daniela Laricchiuta,Juliette Gimenez,Giuseppe Sciamanna,Andrea Termine,Carlo Fabrizio,Francesco Della Valle,Silvia Caioli,Luana Saba,Marco De Bardi,Francesca Balsamo,Anna Panuccio,Noemi Passarello,Anna Mattioni,Elisa Bisicchia,Cristina Zona,Valerio Orlando,Laura Petrosini
出处
期刊:Cell Reports
[Elsevier]
日期:2023-09-01
卷期号:42 (9): 113066-113066
标识
DOI:10.1016/j.celrep.2023.113066
摘要
Fear-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive fear extinction. We find that, already before fear conditioning, specific morphological, electrophysiological, and transcriptomic patterns of cortical and amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, we show the possibility to rescue inefficient fear extinction by activating infralimbic pyramidal neurons and to impair fear extinction by activating prelimbic pyramidal neurons.
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