医学
喉咙痛
入射(几何)
置信区间
队列
接种疫苗
优势比
队列研究
儿科
内科学
免疫学
物理
光学
作者
Weien Yu,Yumei Guo,Tianchang Hu,Yuqi Liu,Qing‐Hua Fan,Lei Guo,B. Zheng,Yide Kong,Haoxiang Zhu,Jia-Kuo Yu,Shiqi Chen,Yongmei Zhang,Jinyu Wang,Fahong Li,Feifei Yang,Yue-E Wang,Yan Zhu,Yuxian Huang,Zhongliang Shen,Yiwen Ruan,Richeng Mao,Jiming Zhang
摘要
During March 2022 to January 2023, two Omicron waves hit Shanghai and caused a massive number of reinfections. To better understand the incidence and clinical characteristics of SARS-CoV-2 reinfection in Shanghai, China, we conducted a multicenter cohort study. COVID-19 patients first infected with BA.2 (March 1, 2022-May 23, 2022) who were quarantined in Huashan Hospital, Renji Hospital, and Shanghai Jing'an Central Hospital were followed up for reinfection from June 1, 2022 to January 31, 2023. Of 897 primary infections, 148 (16.5%) experienced reinfection. Incidence rate of reinfection was 0.66 cases per 1000 person-days. Female gender (adjusted odds ratio [aOR]= 2.19, 95% confidence interval [CI]: 1.29-3.83) was a risk factor for reinfection. The four most common symptoms of reinfections during the circulation of BA.5 sublineages were cough (62.59%), sore throat (54.42%), fatigue (48.98%), and fever (42.57%). Having received a booster vaccination was not associated with reduced severity of reinfection in comparison with not having received booster vaccination. After matched 1:1 by age and sex, we found that reinfections with BA.5 sublineages had significantly lower occurrence and severity of fever, fatigue, sore throat, and cough, as compared to primary infections with BA.5 sublineages. SARS-CoV-2 Omicron reinfections were less severe than Omicron primary infections during the circulation of the same subvariant. Protection offered by both vaccination and previous infection was poor against SARS-CoV-2 reinfection.
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