医学
糖尿病足
糖尿病
糖尿病足溃疡
机制(生物学)
伤口愈合
发病机制
重症监护医学
生物信息学
缺氧(环境)
外科
内科学
内分泌学
哲学
认识论
生物
化学
有机化学
氧气
作者
Dong Mei Zhu,Wuhan Wei,Jingyu Zhang,Bingkun Zhao,Qiang Li,Peisheng Jin
出处
期刊:Heliyon
[Elsevier]
日期:2024-02-01
卷期号:10 (3): e24656-e24656
被引量:1
标识
DOI:10.1016/j.heliyon.2024.e24656
摘要
Diabetic foot ulcer (DFU) is a chronic complication of diabetes. Wound healing in patients with DFU is generally very slow, with a high recurrence rate even after the ulcer healed. The DFU remains a major clinical challenge due to a lack of understanding of its pathogenesis. Given the significant impact of DFU on patient health and medical costs, enhancing our understanding of pathophysiological alterations and wound healing in DFU is critical. A growing body of research has shown that impaired activation of the HIF-1 pathway in diabetics, which weakens HIF-1 mediated responses to hypoxia and leads to down-regulation of its downstream target genes, leading to incurable diabetic foot ulcers. By analyzing and summarizing the literature in recent years, this review summarizes the mechanism of HIF-1 signaling pathway damage in the development of DFU, analyzes and compares the application of PHD inhibitors, VHL inhibitors, biomaterials and stem cell therapy in chronic wounds of diabetes, and proposes a new treatment scheme mediated by participation in the HIF-1 signaling pathway, which provides new ideas for the treatment of DFU.
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