INTRODUCTION: Oral diseases (OD), common dental caries and periodontitis are a major public health problem. Poor oral hygiene has been associated with OD, causing tooth loss, which leads to disability and compromised patients´ oral health. In Rwanda, OD is among the leading causes of morbidity at the health center level. Therefore, the purpose of this study was to assess the knowledge, attitude, and oral health practices among adult participants in Rwanda. METHODS: a descriptive cross-sectional study was done among participants attending public health facilities in Nyarugenge District, Rwanda. Participants were interviewed using a structured questionnaire. The data were analyzed using frequency distribution, percentage distribution, and bivariate and multivariate logistic regression at a 5% significant level.