普鲁兰
胶粘剂
自愈水凝胶
材料科学
光动力疗法
光敏剂
抗菌剂
化学
化学工程
纳米技术
高分子化学
有机化学
图层(电子)
多糖
工程类
作者
Sónia N. Pedro,Bruno F. A. Valente,Carla Vilela,Helena Oliveira,Adelaide Almeida,Mara G. Freire,Armando J. D. Silvestre,Carmen S.R. Freire
标识
DOI:10.1016/j.mtbio.2023.100733
摘要
Antimicrobial photodynamic therapy (aPDT) is a potent tool to surpass the global rise of antimicrobial resistance; still, the effective topical administration of photosensitizers remains a challenge. Biopolymer-based adhesive films can safely extend the residence time of photosensitizers. However, their wide application is narrowed by their limited water absorption capacity and gel strength. In this study, pullulan-based films with a switchable character (from a solid film to an adhesive hydrogel) were developed. This was accomplished by the incorporation of a betaine-based deep eutectic solvent (DES) containing curcumin (4.4 μg.cm-2) into the pullulan films, which tuned the films' skin moisture absorption ability, and therefore they switch into an adhesive hydrogel capable of delivering the photosensitizer. The obtained transparent films presented higher extensibility (elongation at break up to 338.2%) than the pullulan counterparts (6.08%), when stored at 54% of relative humidity, and the corresponding hydrogels a 4-fold higher adhesiveness than commercial hydrogels. These non-cytotoxic adhesives allowed the inactivation (∼5 log reduction), down to the detection limit of the method, of multiresistant strains of Staphylococcus aureus in ex vivo skin samples. Overall, these materials are promising for aPDT in the treatment of resistant skin infections, while being easily removed from the skin.
科研通智能强力驱动
Strongly Powered by AbleSci AI