Indole C5‐Selective Bromination of Indolo[2,3‐a]quinolizidine Alkaloids via in Situ‐Generated Indoline Intermediate

This Cover Feature illustrates the indole C5-selective bromination and subsequent derivatization of indolo[2,3-a]quinolizidine alkaloids. The background depicts temari balls, a form of Japanese folk art and craft. Temari balls are meticulously created by stitching together silk threads with precision. We liken this precision and the connectivity between the temari balls to our discovered site-selective reaction. More information can be found in the Research Article by H. Ishikawa and co-workers (DOI: 10.1002/chem.202401153).