核酸
遗传增强
医学
伤口愈合
慢性伤口
小RNA
重症监护医学
伤口处理
生物
外科
基因
生物化学
作者
Rajalekshmy Girishkumar Padmakumari,Caroline Diana Sherly,M.R. Rekha
出处
期刊:Therapeutic Delivery
[Newlands Press Ltd]
日期:2022-06-01
卷期号:13 (6): 339-358
被引量:2
标识
DOI:10.4155/tde-2022-0003
摘要
Though wound care has advanced, treating chronic wounds remains a challenge and there are many clinical issues that must be addressed. Gene therapy is a recent approach to treating chronic wounds that remains in its developmental stage. The limited reports available describe the therapeutic applications of various forms of nucleic acid delivery for treating chronic wounds, including DNA, mRNA, siRNA, miRNA and so on. Though these bioactive molecules represent great therapeutic potential, sustaining their bioactivity in the wound bed is a challenge. To overcome this hurdle, delivery systems are also being widely investigated. In this review, nucleic acid-based therapy and its delivery for treating chronic wounds is discussed in detail.
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