Integrated analysis of bulk RNA and single-cell RNA sequencing data reveals potential biomarkers and immune infiltrates associated with N7-methylguanosine in osteoarthritis

Our study revealed four m7G regulators, including EIF1, JUND, NUDT16L1 , and NCBP1 , as novel biomarkers that may be associated with the immune infiltration during the progression of OA. Moreover, EIF1 and JUND may serve as potential therapeutic targets for preventing cartilage degeneration. However, further experiments are required to elucidate the molecular mechanisms underlying OA.