生物
免疫系统
背景(考古学)
疾病
获得性免疫系统
适应(眼睛)
先天免疫系统
发病机制
医学
神经科学
免疫学
B细胞
抗体
病理
古生物学
作者
Luigi Adamo,Cibele Rocha‐Resende,Douglas L. Mann
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2020-04-26
卷期号:38 (1): 99-121
被引量:30
标识
DOI:10.1146/annurev-immunol-042617-053104
摘要
B cells are traditionally known for their ability to produce antibodies in the context of adaptive immune responses. However, over the last decade B cells have been increasingly recognized as modulators of both adaptive and innate immune responses, as well as players in an important role in the pathogenesis of a variety of human diseases. Here, after briefly summarizing our current understanding of B cell biology, we present a systematic review of the literature from both animal models and human studies that highlight the important role that B lymphocytes play in cardiac and vascular disease. While many aspects of B cell biology in the vasculature and, to an even greater extent, in the heart remain unclear, B cells are emerging as key regulators of cardiovascular adaptation to injury.
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