功能磁共振成像
鹿特丹研究
睡眠(系统调用)
静息状态功能磁共振成像
人口
大脑活动与冥想
磁共振成像
血氧水平依赖性
心理学
听力学
神经科学
医学
脑电图
放射科
操作系统
环境卫生
计算机科学
作者
Thom S Lysen,Hazel I. Zonneveld,Ryan L. Muetzel,Ikram,Annemarie I. Luik,Meike W. Vernooij,Henning Tiemeier
出处
期刊:VSNU Open Access deal
日期:2020-02-26
摘要
Sleep problems increase with ageing. Increasing evidence suggests that sleep problems are not only a consequence of age-related processes, but may independently contribute to developing vascular or neurodegenerative brain disease. Yet, it remains unclear what mechanisms underlie the impact sleep problems may have on brain health in the general middle-aged and elderly population. Here, we studied sleep's relation to brain functioning in 621 participants (median age 62 years, 55% women) from the population-based Rotterdam Study. We investigated cross-sectional associations of polysomnographic and subjectively measured aspects of sleep with intrinsic neural activity measured with resting-state functional magnetic resonance imaging on a different day. We investigated both functional connectivity between regions and brain activity (blood-oxygen-level-dependent signal amplitude) within regions, hierarchically towards smaller topographical levels. We found that longer polysomnographic total sleep time is associated with lower blood-oxygen-level-dependent signal amplitude in (pre)frontal regions. No objective or subjective sleep parameters were associated with functional connectivity between or within resting-state networks. The findings may indicate a pathway through which sleep, in a ‘real-life’ population setting, impacts brain activity or regional brain activity determines to
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