Anti-fatigue activity of gardenia yellow pigment and Cistanche phenylethanol glycosides mixture in hypoxia

The plateau, which has a unique geographical environment, forms extremely harsh climate conditions. Compared with that of people in the plains, the athletic ability of people on the plateau is significantly decreased. People who enter the plateau from the plains for short time periods will suffer from metabolic dysfunction, productivity loss, bradykinesia and a significant decrease in overall exercise endurance, which results in exercise fatigue. To investigate the anti-fatigue activity of gardenia yellow pigment and Cistanche phenylethanoid glycosides mixture under hypoxia, we performed anti-hypoxia, normoxia anti-fatigue and hypoxia anti-fatigue experiments. The gardenia yellow pigment and Cistanche phenylethanoid glycosides mixture has good anti-hypoxia and anti-fatigue effects under hypoxia, can significantly prolong the anti-anoxia time of mice, and prolong the exhausted swimming time of mice under normoxic and hypoxic conditions. The mechanisms may be related to reducing the accumulation of bad metabolites, increasing energy reserves, improving free radical scavenging capacity, increasing related metabolic enzymes activities, reducing apoptosis and inhibiting the infiltration of inflammatory cells. The gardenia yellow pigment and Cistanche phenylethanoid glycosides mixture is a potential functional product to improve hypoxic exercise fatigue.