Efficacy of the use of fractional CO2RE intima laser treatment in stress and mixed urinary incontinence

医学 尿失禁 性功能 前瞻性队列研究 不利影响 内科学 泌尿科
作者
Santiago Palacios,Marieta Ramírez
出处
期刊:European Journal of Obstetrics & Gynecology and Reproductive Biology [Elsevier BV]
卷期号:244: 95-100 被引量:13
标识
DOI:10.1016/j.ejogrb.2019.10.048
摘要

Objective The objective of this clinical study was to evaluate the efficacy of a vaginal CO2 laser treatment (CO2RE Intima) in patients with moderate, severe and very severe stress urinary incontinence (SUI) or mixed urinary incontinence (MUI), as well as its impact in sexual relations. Design This was a single-center, prospective, interventional study that included 25 women aged 35–68 years who presented with moderate, severe and very severe symptoms of SUI or MUI, based on Sandvik index and ICIQ-UI scores. A series of three fractional micro-ablative CO2 vaginal laser treatment sessions was performed, each spaced 4–6 weeks apart. Improvements were measured and evaluated using scores from validated questionnaires including the International Consultation on Incontinence Questionnaire (ICIQ-IU), the Sandvik severity index, and the Female Sexual Function Index (FSFI). Adverse events were recorded throughout the study and assessed using the Common Side Effect Questionnaire that evaluates pain, hemorrhage, burn, bruising and edema. Results CO2RE intima laser treatment resulted in a significant improvement (P < 0.001) in the scores of both the ICIQ-UI questionnaire and the Sandvik index, after the 2nd session; and this significance persisted after the 3rd treatment session. Improvements in UI severity was also achieved; after the 1st laser treatment, a significant improvement in severity was seen (p < 0.01), the significance of which showed to increase after the 2nd and 3rd treatment sessions (p < 0.001). Improvement related to the type of UI measured with the ICIQ questionnaire was significant in both cases with SUI (p = 0.035) and MUI (p < 0.001) after the second treatment. This difference persisted after the 3rd treatment in cases of MUI and the trend, though not the statistical significance, persisted in SUI cases, (p = 0.197). Improvement in severity was significant in both SUI and MUI types, from the first treatment to the end of the study. Sexual function of patients as reflected in the FSFI questionnaire scores also showed to improve; the difference was significant after the second session (p = 0.013) and persisted at the end of the study (p = 0.047). Conclusion Fractional, micro-ablative CO2RE Intima laser treatment is a minimally invasive procedure that can significantly improve moderate and severe SUI and MUI. It also improves sexual function in women with these types of incontinence. Though our positive results are promising, this preliminary data must be confirmed with other studies.
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