[Progress in the application of exposomics in risk assessment of environmental chemicals].

With the increasing number of environmental chemicals, the risk assessment system based on animal toxicity testing is difficult to satisfy the current demands and needs to be reformed urgently. With the wide application of high-throughput screening technology, the advantage of exposomics in risk assessment is gradually emerging. Exposomics aims to study the health effects of mixed environmental exposure at different stages of life (especially in the early stage of life) through the dynamic monitoring of external and internal exposure levels. Exposomics is introduced into risk assessment to systematically study gene-environment interaction so as to provide a reliable basis for the construction of exposure-biomarker-disease network. This review summarized the importance and application prospect of exposomics in risk assessment of environmental chemicals in terms of the research progress, application in risk assessment and existing problems, opportunities and challenges.进入环境化学物的数量日益增长导致基于动物毒性测试的风险评估体系难以满足当前需求，亟待变革。伴随高通量检测技术的广泛应用，暴露组学在风险评估中的应用价值逐渐显现，通过对环境外暴露和机体内暴露水平的动态监测，研究生命不同时期（尤其是生命早期）环境混合暴露对健康的影响。在风险评估中引入暴露组学，系统研究基因-环境交互作用，为构建暴露-生物标志物-疾病发生网络提供可靠依据。本综述从暴露组学研究进展、在风险评估中的应用和当前存在的问题、机遇与挑战，概述暴露组学在环境化学物风险评估中的重要性和应用前景。.