清道夫受体
癌症
百里香醌
自噬
传出细胞增多
癌症研究
细胞生物学
焊剂(冶金)
生物
癌细胞
化学
生物化学
胆固醇
脂蛋白
巨噬细胞
细胞凋亡
遗传学
体外
抗氧化剂
有机化学
作者
Dongdong Wang,Jiansheng Huang,Ting Gui,Yujun Yang,Tingting Feng,Nikolay Tzvetkov,Xiuxiang Tao,Zhibo Gai,Ying Zhou,Jingjie Zhang,Atanas G. Atanasov
标识
DOI:10.1016/j.semcancer.2019.12.025
摘要
Scavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi-directional flux of free cholesterol. Recently, SR-BI has also been identified as a potential marker for cancer diagnosis, prognosis, or even a treatment target. Natural products are a promising source for the discovery of new drug leads. Multiple natural products were identified to regulate SR-BI protein expression. There are still a number of challenges in modulating SR-BI expression in cancer and in using natural products for modulation of such protein expression. In this review, our purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulating SR-BI expression, as well as to provide an overview of natural products that regulate SR-BI expression.
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