Recent Advances in the Synthesis of Acyl Fluorides

Abstract Acyl fluorides are valuable intermediates in organic synthesis. They are increasingly employed in peptide synthesis, in challenging esterification and amidation reactions or in transition-metal-catalyzed transformations. This review summarizes recent advances in their preparation. 1 Introduction 2 Nucleophilic Fluorination 2.1 α-Fluoroamine Reagents 2.2 Sulfur-Based Reagents 2.3 Metal Catalysts 2.4 Phosphorus-Based Reagents 2.5 N,N′-Dicyclohexylcarbodiimide/HF·Pyridine 2.6 Uranium Hexafluoride 2.7 Bromine Trifluoride 3 Radical Fluorination 4 Conclusion