胆固醇
产量(工程)
化学
反应条件
组合化学
生化工程
有机化学
材料科学
生物化学
催化作用
工程类
冶金
作者
Xing-Zi Li,Chenchen Li,Chengyu Jiang,Zhiliang Jing,Xiang-Zhong Gu,Hao-Jie Ni,Wen‐Wei Qiu
出处
期刊:Steroids
[Elsevier]
日期:2022-02-01
卷期号:178: 108967-108967
被引量:1
标识
DOI:10.1016/j.steroids.2022.108967
摘要
Currently, the market demand of the non-animal-derived cholesterol is increasing. A novel synthetic route of producing cholesterol was developed through multiple reactions from plant-sourced and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, reaction temperatures, bases and reducing agents of the route were investigated and optimized. In this straightforward synthetic pathway of cholesterol, most of the reaction steps possess high conversions with average yields of 94%, and the overall yield is up to 74% (5 steps) from the BA. The epicholesterol and were also synthesized. This promising route offers economical and efficient strategies for potential large-scale production of plant-derived cholesterol.
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