生物
DNA再复制
DNA复制
染色体复制控制
真核细胞DNA复制
复制前复合体
原点识别复合体
许可因素
DNA复制因子CDT1
遗传学
复制因子C
复制(统计)
基因组不稳定性
细胞生物学
复制计时
DNA损伤
计算生物学
DNA
病毒学
出处
期刊:Molecular Cell
[Elsevier]
日期:2022-06-01
卷期号:82 (12): 2298-2314
被引量:24
标识
DOI:10.1016/j.molcel.2022.05.004
摘要
Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA replication machinery is highly accurate, the process of DNA replication is constantly challenged by DNA damage and other intrinsic and extrinsic stresses throughout the genome. A variety of cellular stresses interfering with DNA replication, which are collectively termed replication stress, pose a threat to genomic stability in both normal and cancer cells. To cope with replication stress and maintain genomic stability, cells have evolved a complex network of cellular responses to alleviate and tolerate replication problems. This review will focus on the major sources of replication stress, the impacts of replication stress in cells, and the assays to detect replication stress, offering an overview of the hallmarks of DNA replication stress.
科研通智能强力驱动
Strongly Powered by AbleSci AI