A dual-responsive nanozyme sensor with ultra-high sensitivity and ultra-low cross-interference towards metabolic biomarker monitoring

M, respectively. Importantly, the DNS-based analytical system not only enables visual discrimination and accurate assay of glucose and caffeine in biofluids, but also exhibits negligible cross-interference between glucose and caffeine determination. The combined characteristics of high selectivity, enhanced accuracy and superior quantitative performance make our platform suitable for the point-of-care monitoring of chronic-disease-related metabolic biomarkers.