纳米纤维
表面改性
药物输送
化学
肝素
粘附
细胞粘附
生物物理学
组织工程
化学工程
高分子化学
材料科学
生物医学工程
纳米技术
作者
Meng Guo,Xiaofeng Wang,Yajing Liu,Haichang Yu,Jiahui Dong,Zhixiang Cui,Zhiyuan Bai,Kecheng Li,Qian Li
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2022-03-02
卷期号:23 (3): 1337-1349
标识
DOI:10.1021/acs.biomac.1c01572
摘要
The functionalization of the fibrous scaffolds including drug loading and release is of significance in tissue engineering and regenerative medicine. Our previous results have shown that the shish-kebab structure-modified fibrous scaffold shows a completely different microenvironment that mimics the topography of the collagen fibers, which interestingly facilitates the cell adhesion and migration. However, the functionalization of the unique structure needs to be further investigated. In this study, we modified the heparin-loaded fiber with a shish-kebab structure and tuned the kebab structure as the barrier for the sustained release of heparin. The introduction of the kebab structure increases the diffusion energy barrier by extending the diffusion distance. Moreover, the discontinued surface topography of the shish-kebab structure altered the surface chemistry from hydrophobic for the original poly(ε-caprolactone) (PCL) nanofibers to hydrophilic for the PCL nanofibers with the shish-kebab structure, which might have inhibited the activation of fibrinogen and thus improved the anticoagulant ability. This synergistic effect of heparin and the kebab structure significantly promotes the endothelial cell affinity and antithrombogenicity. This method might be a viable and versatile drug delivery strategy in vascular tissue engineering.
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