脱羧
化学
芳基
分子内力
催化作用
自由基环化
组合化学
级联
转化(遗传学)
药物化学
有机化学
烷基
色谱法
生物化学
基因
作者
Pengcheng Du,Qianqian Sun,Hongxiao Li,Jianhua Zhang,Hongmei Deng,Haizhen Jiang
标识
DOI:10.1002/asia.202200088
摘要
An efficient method for silver-catalyzed radical cascade arylthiodifluoromethylation/cyclization of isonitriles is disclosed. The transformation comprised addition of an arylthiodifluoromethyl radical generated in situ by the oxidative decarboxylation of arylthiodifluoroacetic salts to the isonitrile functionality to construct an ArSCF2 -C bond, followed by intramolecular cyclization to eventually afford 6-phenanthridinyldifluoromethyl aryl thioethers. The protocol provided a variety of 6-phenanthridinyldifluoromethyl aryl thioethers in medium to excellent yields with a good functional group tolerance under mild reaction conditions.
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