降纤酶
医学
肝静脉闭塞性疾病
化疗
造血干细胞移植
小儿癌症
并发症
癌症
威尔姆斯瘤
外科
移植
内科学
作者
Marc R Lawrence,Mylene Bassal,Raveena Ramphal,Donna L. Johnston
出处
期刊:Journal of Pediatric Hematology Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2022-04-01
卷期号:44 (3): e788-e791
被引量:1
标识
DOI:10.1097/mph.0000000000002177
摘要
Sinusoidal obstruction syndrome (SOS), formerly veno-occlusive disease (VOD), in pediatric cancer patients often presents as a complication of hematopoietic stem cell transplantation, and less commonly secondary to nontransplant-associated chemotherapy. Therapy with defibrotide is well-described as standard care for transplant-associated SOS/VOD, but the treatment of nontransplant-associated SOS/VOD is less clear. We report a 3-year-old with relapsed Wilms tumor and recurrent SOS/VOD, with successful use of defibrotide during chemotherapy. A review of pediatric cancer patients with nontransplant-associated SOS/VOD treated with defibrotide revealed 83 patients, and 66 were in remission. This review supports early treatment with defibrotide in patients with nontransplant-associated SOS/VOD.
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