伤口愈合
二甲双胍
血管生成
自愈水凝胶
炎症
再生(生物学)
体内
药理学
伤口敷料
生物医学工程
医学
化学
材料科学
外科
癌症研究
免疫学
细胞生物学
生物
糖尿病
生物技术
内分泌学
有机化学
复合材料
作者
Tongtong Leng,Yidan Wang,Wei Cheng,Wensi Wang,Xinfeng Qu,Bo Lei
出处
期刊:Biomaterials advances
日期:2022-04-01
卷期号:135: 212737-212737
被引量:7
标识
DOI:10.1016/j.bioadv.2022.212737
摘要
Highly efficient wound healing and skin regeneration remain a challenge. Long-term inflammation and bacterial infection can inhibit the healing process and lead to the scar formation. Here, we report a hydrogel (FEM) formed by self-assembly of ε-poly-l-lysine-F127-ε-poly-l-lysine (EPL-F127-EPL) and metformin for wound repair. Especially, the role of metformin-based antibacterial hydrogel in wound healing and repair was investigated for the first time. FEM has inherent multifunctional properties, including controlled metformin release, anti-inflammatory and antibacterial activity, temperature responsiveness, injectable and self-healing capabilities. The in vivo results showed that FEM dressings accelerated the wound healing by stimulating the angiogenesis process of the wound tissue and anti-inflammation. This study shows that the multifunctional metformin-contained hydrogel scaffolds could enhance the wound repair through the anti-inflammation and accelerated angiogenesis, which could also expand the biomedical applications of metformin-based biomaterials.
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